"Conditioning"--IL-1 et al.

F. Frank LeFever flefever at ix.netcom.com
Sat Jun 20 15:31:02 EST 1998


I've discussed the idea of IL-1 conditioning with Ader (he was one of
my speakers at the May 2 conference on "Neuropsychology and the
Neuroimmune Dialogue"--announced to bionet.immunology).  He agreed it
is a reasonable possibility, but did not know of any direct evidence. 
Much of his own work looks at agents or actions farther "downstream",
less on intermediate steps.

Maybe I should emphasize and make explicit: I'm really not interested
in "immune responses" in general, and certainly not in (e.g.) influence
of social or behavioral factors on health, resistance to disease, etc.
My interest is rather narrowly focused on IL-1, TNF, NO (and/or NOS),
and mast cells, and possible long-range "conditioning" (Pavlovian or
otherwise); on a time-order PERHAPS approaching that of responses based
on antigen recognition, but not this mechanism.

I'll certainly check out Lyle and Hiramoto.  Thanks!



In <358A8A36.40B1 at pilot.msu.edu> Hao Chen <chenhao at pilot.msu.edu>
writes: 
>
>F. Frank LeFever wrote:
>Pavlovian conditioning of immune response is the ongoing research in
>several labs in the US as far as I know. They are Robert Ader and
>Nicholas Cohen from University of Rochester, Donald Lysle from
>University of North Carolina, and also Raymond Hiramoto from
University
>of Alabama at Birmingham. 
>
>check out my psychoneuroimmunology link page at 
>
>http://www.msu.edu/user/chenhao/pniweb.htm
>
>Hao Chen
>
>
>> >In <6ldaa6$ahc at dfw-ixnews9.ix.netcom.com> flefever at ix.netcom.com(F.
>> >Frank LeFever) writes:
>> >>
>> >>There are many demonstrations of "conditioning" in the sense of
acute
>> >>changes in reactions of one or the other system after some
treatment
>> >or other (e.g. reaction to hypoxia an hour or so after mechanical
>> brain
>> >>trauma, or vice versa).
>> >>
>> >>I am not interested in these.
>> >>
>> >>I am looking for LONG-TERM "conditioning"--on the order of
Pavlovian
>> >>conditioning or on the order of immnological "conditioning" (e.g.
>> >>specific antigen recognition, etc.).
>> >>
>> >>For example: IL-1 production can be increased by various
>> manipulations
>> >>(e.g. brain trauma, hypoxia, LPS exposure, etc.); does a REMOTE
>> >history of this  (e.g. at LEAST a few weeks prior) influence
>> subsequent
>> >IL-1 responses?  e.g. influence on threshold for stimulation, on
>> >latency of response, on rate of production, on co-production of
(e.g.)
>> >IL-1a (endogenous competitive ligand), or--?
>> >>
>> >>Interested in brain but surely info from anyplace else (ovarian
>> >tissue, gut, heart, liver, whtever) could be useful.
>> >>
>> >>Not ONLY IL-1--what about TNF? NO? and (beond this realm) NGF et
al.?
>> >>
>> >>re Pavlovian conditioning: 1987 paper on conditioning of mast cell
>> >>response (MacQueen) much cited, but don't know if actually
replicated
>> >>or extended...
>> >>
>> >>Post to bionet.immunology OR email me direct OR (if longer
>> >>communication, reprint, etc.): FAX (914) 786-4978 (att: LeFever)
>> >>
>> >>MAIL:   F. Frank LeFever, Ph.D.
>> >>        Helen Hayes Hospital
>> >>        West Haverstraw, NY 10993, USA
>> >>
>> >




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