petergun wrote: > > Dear sir! > I have made a fusion protein(cytokine-IgM),but it is not stable. > The fusion protein can be find as hexamer or pentamer on SDS gel, > but some days later it degeaded in monomer all of them. > I think ,the unstable phenomenon of the fusion protein is occoured > from nature of IgM.How to solve this unstable problem of IgM. > Yhank you.