MHC-I viral Ag presentation

Victor DeFilippis vrdefili at DARWIN.BIO.UCI.EDU
Wed May 6 13:08:18 EST 1998

A potentially stupid question follows.  How can Ag's be presented to CD8+
cells (via MHC-I) for viruses which never infect professional APC's?  It's
my (admittedly naive) impression that in order for peptides to be presented
on MHC-I molecules the proteins need to be synthesized in the cytoplasm.
Does this mean that highly tissue specific viruses that totally avoid
replication in APC's never have a CTL response directed toward them?  

Thanks in advance!

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