MHC-I viral Ag presentation

John Richard Seavitt jrseavit at artsci.wustl.edu
Tue May 12 12:33:03 EST 1998

On Fri, 8 May 1998, Bob Scibienski wrote:

> "David R. Johnson" <johnson at biomed.med.yale.edu> wrote:

> >1.) Although it is well established that CD4 cells need "professional" APC for
> >priming, what is the evidence that CD8 cells do not respond to "amateur" APC
> >(e.g. virally infected normal cells)?

> Although this is a "muddy" area, most of the "real world" studies I recall
> suggest that in the absence of good help one does not get get good CTL based
> immunity.  A virgin CTL will probably kill any virally infected cell it
> encounters but this apparently is not sufficient to induce clonal expansion.

Don't forget those experiments with the insulin promoter - viral
glycoprotein transgenics.  The mice express the viral protein in B-islet
cells, have reactive T cells in vitro, but don't get insulitis or diabetes
until you infect them with live virus.

John Seavitt

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