"AIDS Treatment News" online * New Issue #302 (searchable/indexed)

George M. Carter gmc0 at ix.netcom.com
Mon Oct 12 12:53:42 EST 1998


johnburgin at worldnet.att.net wrote:

snip ...

>>Please post statistics showing AZT causes AIDS, especially uncorrelated to
>>HIV infection.
>>
>Journal of the National Cancer Institute 1997; 89:1602-1608

Your cite sucks.  Usually, people provide the authors names and the
title.  In any event, the abstract is posted below.

While these are toxicities that must not be ignored, they are NOT the
same as AIDS.  Your cite only shows you to be a moron.

		George M. Carter

 Natl Cancer Inst 1997 Nov 5;89(21):1602-8 

Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT):
tumorigenicity in mice
and genotoxicity in mice and monkeys.

Olivero OA, Anderson LM, Diwan BA, Haines DC, Harbaugh SW, Moskal TJ,
Jones AB, Rice JM, Riggs CW, Logsdon D, Yuspa SH,
Poirier MC

Division of Basic Sciences, National Cancer Institute, Bethesda, MD
20892-4255, USA. olivero at pop.nci.nih.gov 

BACKGROUND: When given during pregnancy, the drug
3'-azido-2',3'-dideoxythymidine (AZT) substantially reduces
maternal-fetal transmission of human immunodeficiency virus type 1
(HIV-1). However, AZT has been shown to be carcinogenic in adult mice
after lifetime oral administration. In this study, we assessed the
transplacental tumorigenic and genotoxic effects of AZT in the
offspring of CD-1 mice and Erythrocebus patas monkeys given AZT orally
during pregnancy. METHODS: Pregnant mice were given daily doses of
either 12.5 or 25.0 mg AZT on days 12 through 18 of gestation (last
37% of gestation period). Pregnant monkeys were given a daily dose of
10.0 mg AZT 5 days a week for the last 9.5-10 weeks of gestation
(final 41%-43% of gestation period). AZT incorporation into nuclear
and mitochondrial DNA and the length of chromosomal end (telomere) DNA
were examined in multiple tissues of newborn mice and fetal monkeys.
Additional mice were followed from birth and received no further
treatment until subjected to necropsy and complete pathologic
examination at 1 year of age. An anti-AZT radioimmunoassay was used to
monitor AZT incorporation into DNA. RESULTS: At 1 year of age, the
offspring of AZT-treated mice exhibited statistically significant,
dose-dependent increases in tumor incidence and tumor multiplicity in
the lungs, liver, and female reproductive organs. AZT incorporation
into nuclear and mitochondrial DNA was detected in multiple organs of
transplacentally exposed mice and monkeys. Shorter chromosomal
telomeres were detected in liver and brain tissues from most
AZT-exposed newborn mice but not in tissues from fetal monkeys.
CONCLUSIONS: AZT is genotoxic in fetal mice and monkeys and is a
moderately strong transplacental carcinogen in mice examined at 1 year
of age. Careful long-term follow-up of AZT-exposed children would seem
to be appropriate. 

Comments:
     Comment in: J Natl Cancer Inst 1997 Nov 5;89(21):1566-7 
     Comment in: J Natl Cancer Inst 1998 Aug 5;90(15):1171 





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