"AIDS Treatment News" online * New Issue #302 (searchable/indexed)

Carlton Hogan carlton at walleye.ccbr.umn.edu
Fri Oct 16 12:07:46 EST 1998

In article <3624ded3.689754535 at netnews.worldnet.att.net>,
 <johnburgin at worldnet.att.net> wrote:
>On 14 Oct 98 07:59:45 EDT, holzmr01 at mcrcr6.med.nyu.edu (ROBERT S.
>HOLZMAN) wrote:
>>In article <3623dacc.623177053 at netnews.worldnet.att.net>, johnburgin at worldnet.att.net writes:
>>> On 13 Oct 1998 17:12:03 GMT, carlton at walleye.ccbr.umn.edu (Carlton
>>> Hogan) wrote:
>>>>In article <ShzPMvTWl66V at mcrcr6>,
>>>>ROBERT S. HOLZMAN <holzmr01 at mcrcr6.med.nyu.edu> wrote:
>>>>>In article <6vteq4$9jk at dfw-ixnews6.ix.netcom.com>, gmc0 at ix.netcom.com (George M. Carter) writes:
>>>>>> johnburgin at worldnet.att.net wrote:
>>>>>>>>No.  It was just dead cold wrong.  
>>>>>>>Well, have I moved off of the idiotic list, Mr Carter?  I've been
>>>>>>>upgraded to simply dead wrong?  I gave you "A" study, I can give you
>>>>>>>lots more with higher doses.  Want to keep looking foolish?
>>>>>> No, you're still an idiot, not to worry. And wrong, too.
>>>>>> As to other studies using higher doses, yes, there are.
>>>>>> But let's get to the point.'
>>>>>>>no I didn't.  I said higher doses were used than today.  Don't mislead
>>>>>>>our audience.  Remember, they can read too.
>>>>>>> that people were taking 1200 mg or some high dose until the
>>>>>>>protease inhibitors came along, then the dose dropped.  
>>>>>Dosage changed in 1989, quite a bit before PIs came along.
>>>>As I recall it, it was ACTG 002 that drove the change in standard care.
>>>>This was the second trial ever initiated by the ACTG, which (under 
>>>>the name ATEG) was started in 1987.
>>> Was that one for me?  I don't want to sound unappreciative. jb
>>I don't know if it is one for you.  Were you the one who said dosage changed
>>in response to PI availabilty?  Seems like you were arguing that the dosage
>>was reduced in combo therapy.  It was reduced long before.
>>However if it is one for you, take it.  You need it pretty bad.
>I'll stand my ground.  Most of the information that I have is that
>regardless of the amount of reduction, the dosage of the AZT, even at
>600mg is less than it was prior to the PI's "standard" cocktail.

This is SIMPLY NOT TRUE, no matter how much you want it to be.

>Maybe you don't know most physicians as well as I do.

Not counting the 60+ HIV/ID specialists in the CPCRA where I work,
or the 30 some physicians in the Twin Cities AIDS Clinicians group
(where I live)? You are Just plain wrong. If you can find ANY
Physician, ANYWHERE, that treats more than 5 patients with AIDS 
who will confirm your bizarre and unsupported ideas, I would love to 
know about it.

Bob is a full-time physician/researcher. I am a full time clinical 
trialist. Trust me, we are aware of the bigger trends (like lower 
AZT dosage) in our respective worlds. Get over it. You are wrong.
Let's move on.

 |                                                                        |
 |   Carlton Hogan  (carlton at gopher.ccbr.umn.edu)                         |
 |   Community Programs for Clinical Research on AIDS Statistical Center  |
 |   Coordinating Center for Biometric Research                           |
 |   Division of Biostatistics, School of Public Health                   |
 |   University of Minnesota          http://www.biostat.umn.edu/~carlton |
 |   2221 University Ave SE, Suite 200              Voice: (612) 626 8899 |
 |   Minneapolis  MN 55414                            FAX: (612) 626 8892 |
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