MHC restriction questions

Ian A. York iayork at panix.com
Thu Oct 22 16:10:56 EST 1998


In article <362FBCED.1958 at mail.tju.edu>,
mark  <mark.haynes at mail.tju.edu> wrote:
>
>I don't really think you need a system that can differentiate, just a system 
>that deletes reactivity to peptides that find there way to the thymus and get 
>presented via class i or class ii to cd8 or cd4 thymocytes respectively.  
>Everything else is non-self.  You don't need to be tolerant of all the intra 

If "everything else is non-self", then it's differentiating between
self-and non-self.  You've rephrased my point, is all.

>> that shifting the burden of discrimination from a subset of cells to all
>> cells will greatly increase the cost.
>
>Me neither, but I would propose that it would just be shifted to APCs and not 
>every cell.

For MHC class I, every cell *is* an APC.   So, again, you've re-phrased my
point.


-- 
Ian York           |   "I'm not crazy.  You're the one who's crazy.  WE'VE 
(iayork at panix.com) |    GOT YOUR URINE AND WE'RE NOT LETTING IT GO." 
                   |                               -Tjames Madison



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