Rheumatoid arthritis

F. Frank LeFever flefever at ix.netcom.com
Thu Oct 22 22:40:09 EST 1998

Do you keep up with arthritis journals?  e.g. _Arthritis & Rheumatism_
others?  One angle which has interested me (not because of arthritis
but because of my extrapolations to other areas) is the question of
imbalance between  IL-1 and IL-1ra (the latter referring to the
endogenous antagonist or receptor competitor); I believe it was in the
current "A & R" that I saw a very provocative investigation of this

A  couple of years ago (same journal????) I saw a study which raised
the possibility that one mode of action of piroxicam might be
enhancement of IL-1ra production.  (In many respects, piroxicam is a   
VERY unusual NSAID, and I wish there were more BASIC studies of its
characteristics rather than the 101 tedious clinical efficacy studies
comparing it to one or another new contender...)

Have you access to Medline?  get  creative with your "OR" and "AND"
search strategies...

F. Frank LeFever, Ph.D.
New York Neuropsychology Group

In <01bdfdc9$5c2abb00$26a226cb at paulgriffin> "Paul Griffin"
<t.s.griffin at picknowl.com.au> writes: 
>I am posting this message in request of information on rheumatoid
>	 I currently have the task of writing a rather extensive review
on the
>immunopathogenesis of rheumatoid arthritis. I have been lead to
>that one possible theory, for which support has dwindled in recent
>was that dysregulation of the innate immune response in the synovium
>be responsible for the recruitment of inflammatory cells and thus
>initiation of the disease. Specifically, it was thought that a
>defect in either macrophage or fibroblast derived synoviocytes results
>the release of inflammatory mediators and subsequent recruitment and
>activation of effector cells. All of the information I have been able
>obtain relates to the interaction between CD4+ T cells and antigen
>presenting cells, and although I need to write about this also, I
>like to be able to cover a number of views. If anyone out there knows
of a
>good reference, book or other source of useful information that can
>me in the right direction they will be doing me a huge favour. Current
>prevalence data would also be useful, particularly for Australia.
>	 Thankyou for taking the time to read my request,
>		 I look forward to hearing from you all,
>					Paul
>					email: t.s.griffin at picknowl.com.au

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