tolerance induction in mice

Hao Xiao haoxiao at immunechem.com
Tue Oct 27 18:21:01 EST 1998


Just radom guess:
B-cell binds hapten (surface antibodies)?
T-cell binds peptide (peptide MHC complex)?

who knows

mark wrote in message <3634D7A1.7CAA at mail.tju.edu>...
>Christiane Hollmann wrote:
>>
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>> Hallo everybody,
>>
>> I just discovered this discussion forum and I am delighted about the
>> tolerance discussion. I am a newcomer in the tolerance field hoping that
>> someone knows an answer to my questions.
>> Is it true that B cell tolerance can be induced by immunizing mice with
>> haptens whereas immunizing with peptides doesnot affect the B cell
>> system? Peptides are meant to induce T cell tolerance but there must be
>> some influence on the B cells via the CD4+ T cells.
>> Does anybody know some literature or is experienced in this fields?
>> Thank´s for any help!
>>
>> Christiane Hollmann
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>
>That is such a broad topic.  Peruse the review journals (I like annual
>reviews of immunology) on tolerance jsut to get an idea of how much is out
>there.  good luck
>markH





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