"AIDS Treatment News" online * New Issue #302 (searchable/indexed)

Andrew Walley awalley at radius.jr2.ox.ac.uk
Wed Oct 28 08:02:33 EST 1998



johnburgin at worldnet.att.net wrote:

> On 27 Oct 1998 17:49:13 GMT, carlton at walleye.ccbr.umn.edu (Carlton
> Hogan) wrote:
>
> >
> >You are a silly and amazingly ignorant man. In the below you state:
> >
> >">If, assuming that you are correct, which I don't believe, that
> >>antibodies do "not" always mean that you have conquered infection, as
> >>I stated before, how can you arbitrarily recommend using them to
> >>signify protection one time(as with prophylactic vaccination against
> >>Hepatitis B and not with HIV?  What, please tell me, would an
> >>individual "vaccinated" against HIV present as proof of immunization?
> >>He would be HIV + of course!  Again, are these "non-neutralizing"
> >>antibodies in the latter case or neutralizing antibodies in the first
> >>case?"
> >
> >Your stupidity is amazing. I never have said that I "reccomend using them
> >to signify protection".
> I never said that YOU did.  You don't treat patients, remember?
> Not only are you a pompous ass, you're a defensive pompous ass.  Talk
> to me, us, about "enhancing" antibodies.  A few of my other ignorant
> medical colleagues, including 2 board certified medical pathologist
> and a molecular biologist are laughing their asses off at your
> bullshit.  Do you really believe that because you say something in
> scientific jargon that people believe it?  If they can't understand
> what you are saying, and they don't know who you are, why should they
> believe you?  Come on, talk to us all, o.k., just me about "enhancing"
> antibodies.  Make your case.  No references to medline searches.  They
> don't bring up the term.

>

Just for you and your colleagues information:

Neutralizing and enhancing activities of human respiratory syncytial virus-specific
antibodies.
       Clin Diagn Lab Immunol. 1996 May;3(3):280-6.
       PMID: 8705669; UI: 96336082.

The effect of enhancing antibodies on TNF interactions with its specific receptor:
consequences for in vitro TNF antiviral activity.
       Biotechnol Ther. 1994;5(1-2):27-45.
       PMID: 7703831; UI: 95218613.

Antibodies to HA and NA augment uptake of influenza A viruses into cells via Fc
receptor entry.
       Virology. 1991 May;182(1):211-9.
       PMID: 2024464; UI: 91220653.

In vitro enhancement of respiratory syncytial virus infection of U937 cells by human
sera.
       J Gen Virol. 1989 Jan;70 ( Pt 1):89-96.
       PMID: 2732688; UI: 89279203.

In vitro enhancement of respiratory syncytial virus infection of U937 cells by human
sera.
       J Gen Virol. 1989 Jan;70 ( Pt 1):89-96.
       PMID: 2732688; UI: 89279203.

Enhancing antibody: a novel component of the immune response.
       Proc Natl Acad Sci U S A. 1982 Jun;79(12):3828-32.
       PMID: 6179088; UI: 82247944.

This ignores the extensive literature associated with HIV and associated
retroviruses where much of the recent work on ehhancing antibodies has been carried
out. However, I thought the references to other fields of research might be less
controversial.

Andrew Walley




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