"AIDS Treatment News" online * New Issue #302 (searchable/indexed)

johnburgin at worldnet.att.net johnburgin at worldnet.att.net
Wed Oct 28 19:28:04 EST 1998


On Wed, 28 Oct 1998 13:02:33 +0000, Andrew Walley
<awalley at radius.jr2.ox.ac.uk> wrote:

>
>
>johnburgin at worldnet.att.net wrote:
>
>> On 27 Oct 1998 17:49:13 GMT, carlton at walleye.ccbr.umn.edu (Carlton
>> Hogan) wrote:
>>
>> >
>> >You are a silly and amazingly ignorant man. In the below you state:
>> >
>> >">If, assuming that you are correct, which I don't believe, that
>> >>antibodies do "not" always mean that you have conquered infection, as
>> >>I stated before, how can you arbitrarily recommend using them to
>> >>signify protection one time(as with prophylactic vaccination against
>> >>Hepatitis B and not with HIV?  What, please tell me, would an
>> >>individual "vaccinated" against HIV present as proof of immunization?
>> >>He would be HIV + of course!  Again, are these "non-neutralizing"
>> >>antibodies in the latter case or neutralizing antibodies in the first
>> >>case?"
>> >
>> >Your stupidity is amazing. I never have said that I "reccomend using them
>> >to signify protection".
>> I never said that YOU did.  You don't treat patients, remember?
>> Not only are you a pompous ass, you're a defensive pompous ass.  Talk
>> to me, us, about "enhancing" antibodies.  A few of my other ignorant
>> medical colleagues, including 2 board certified medical pathologist
>> and a molecular biologist are laughing their asses off at your
>> bullshit.  Do you really believe that because you say something in
>> scientific jargon that people believe it?  If they can't understand
>> what you are saying, and they don't know who you are, why should they
>> believe you?  Come on, talk to us all, o.k., just me about "enhancing"
>> antibodies.  Make your case.  No references to medline searches.  They
>> don't bring up the term.
>
>>
>
>Just for you and your colleagues information:
>
>Neutralizing and enhancing activities of human respiratory syncytial virus-specific
>antibodies.
Thank you, now please explain their role in the HIV=AIDS issue. jb
>       Clin Diagn Lab Immunol. 1996 May;3(3):280-6.
>       PMID: 8705669; UI: 96336082.
>
>The effect of enhancing antibodies on TNF interactions with its specific receptor:
>consequences for in vitro TNF antiviral activity.
>       Biotechnol Ther. 1994;5(1-2):27-45.
>       PMID: 7703831; UI: 95218613.
>
>Antibodies to HA and NA augment uptake of influenza A viruses into cells via Fc
>receptor entry.
>       Virology. 1991 May;182(1):211-9.
>       PMID: 2024464; UI: 91220653.
>
>In vitro enhancement of respiratory syncytial virus infection of U937 cells by human
>sera.
>       J Gen Virol. 1989 Jan;70 ( Pt 1):89-96.
>       PMID: 2732688; UI: 89279203.
>
>In vitro enhancement of respiratory syncytial virus infection of U937 cells by human
>sera.
>       J Gen Virol. 1989 Jan;70 ( Pt 1):89-96.
>       PMID: 2732688; UI: 89279203.
>
>Enhancing antibody: a novel component of the immune response.
>       Proc Natl Acad Sci U S A. 1982 Jun;79(12):3828-32.
>       PMID: 6179088; UI: 82247944.
>
>This ignores the extensive literature associated with HIV and associated
>retroviruses where much of the recent work on ehhancing antibodies has been carried
>out. However, I thought the references to other fields of research might be less
>controversial.
>
>Andrew Walley
>




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