"AIDS Treatment News" online * New Issue #302 (searchable/indexed)

Marnix L. Bosch marnix at u.washington.edu
Fri Oct 30 11:58:55 EST 1998


In article <363928d8.273477005 at netnews.worldnet.att.net>,
johnburgin at worldnet.att.net wrote:

> On Thu, 29 Oct 1998 16:46:20 -0700, marnix at u.washington.edu (Marnix L.
> Bosch) wrote:

> >The point you were trying to make was that presence of antibodies
> >signified protection. You were shown to be wrong. Anything else you can't
> >explain ? 
>
> Marnix, Marnix, Marnix.  What have I been shown wrong for?  

see above

> You still,
> after all this time haven't explained why we, the medical
> profession(physicians, dentists, nurses, PA's, laboratory technicians,
> etc-except you, knothead) depend upon an explanation for immunity upon
> antibody formation, in general if that makes you feel any better, and
> HIV does not produce an effective antigen that results in the body
> producing an effective antibody complex to respond to the alien
> entity. 

Who said antibodies to HIV-1 are not effective ? The mere fact that HIV-1
is mutating away from the effects of the produced antibodies shows them to
be effective. Just not 100%, for various reasons. Let me know if you're
interested ?

> The only excuse you and your asshole buddies keep using is
> mutation.  I'll tell you what's mutating, your explanation.  Keep it
> up, it gets better and better.  Enhancing antibodies, enchanting
> antibodies, exquisite antibodies, call them what you will, it's still
> b.s.  Please answer at least one of my questions without a sarcastic
> nihilistic comment, what will the antibody status be for an individual
> "immunized" against the HIV retrovirus?  End of story.  I'm sure you
> recommend cocktail therapy for even those people.  You're sick.jb

I would not recommend antivirals for anyone who has only an antibody test
to demonstrate HIV status. As for your question: such a person would have
antibodies to the viral proteins contained in the vaccine prep. This could
label him/her seropositive. Various proposals are under discussion as to
how to distinguish this status from true seropositivity resulting from
infection. All vaccines in clinical trials to date (that I'm aware off)
use only selected HIV-1 antigens, mostly envelope. Thus immunized
individuals would not be seropositive for HIV-1 but only show reactivity
to a limited subset of HIV-1 antigens.

Marnix Bosch



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