DNA Vaccine and Immune response

George M. Carter gmc0 at ix.netcom.com
Wed Sep 30 09:55:32 EST 1998


"Joe Chandler" <mbiotec at maine.rr.com> wrote:

>A couple of thoughts:
>1. Is it possible that the level of protein epression is now equivilent to
>the level of antibody expression.  Thus, all the antibody is cleared as
>ag/ab complex.

Could they check for CICs?  Or just see if the critters' kidneys are
clogged?

>Or, 2.  how can you be sure that there is still expression of the viral
>antigens.  Have you continued to immunize the mice with the DNA vector?
>[Curious to hear from others as we are initiating a DNA immunization
>program here.]

And what about the cell-mediated response?

George





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