DNA Vaccine and Immune response

[Joe Chandler]

A couple of thoughts:
1. Is it possible that the level of protein epression is now equivilent to
the level of antibody expression.  Thus, all the antibody is cleared as
ag/ab complex.
Or, 2.  how can you be sure that there is still expression of the viral
antigens.  Have you continued to immunize the mice with the DNA vector?
[Curious to hear from others as we are initiating a DNA immunization
program here.]
Regards,
JPC

vinsin at my-dejanews.com wrote in article
<6ut566$4il$1 at nnrp1.dejanews.com>...
> 
> 
> 
> Dear Friends,
> 
> I have been using DNA vaccine against a viral infection in a murine
model.
> Initially I got good humoral response which is now not being generated.
> 
> Suggestions invited.
> 
> Thank you in advance.
> 
> Vinay
> 
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