Age of mice??

[wayne.conlan at nrc.ca]

In article <371BDD1A.4FD8 at inav.net>,
  Robert Jensen <rjjensen at inav.net> wrote:
> Brian asked if anybody knew if age effected success rate on hybridoma
> fusions. Jay answers that he has no referances but he "knows" that age
> does effect success. While I would not at all be surprized to see that
> age does have an effect, Jay gave us absolutely no insight. Where is
> your proof Jay? Come on now are we just supposed to take your word on
> this? I didnt think science worked that way.
>
> rjj
>

Hi:  Sorry, I can't answer this particular question.  However, I would like
totake issue with the statement that mice several months old are equivalent
to human geriatrics and immunosenescent. In my hands 2+ year old mice seem at
least as immunocompetent as 8 week old mice, at least in terms of their
ability to cope with experimantal infections with a variety of bacterial
pathogens.

Regards,


Wayne


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