vigor wrote:
>> Hi,
> I'm a PhD student who is very interested in the field of immunology.
> Recently, the cross-priming pathway by which acceptor professional APC
> (= dendritic cells; DC) acquire antigen from donor cells to elicit an
> antigen-specific CTL respons has been studied in detail by the group of
> N. Bhardwaj et al. (Nature 1998; 392: 86-89 & J Exp Med 1998; 188:
> 1359-1368. This group demonstrated that the cross-priming phenomenon can
> be explained by the phagocytosis, processing and presentation of
> antigens derived from apoptotic and not necrotic cells on MHC class I
> molecules.
> Well now, my question is how this theory fits with the "danger" model of
> P. Matzinger (Ann Rev Immunol 1994; 12: 991-1045)? According to
> Matzinger, the DC must become activated through a danger signal
> (necrosis, viral infection,...) in order to function as a professional
> (effector) APC capable of activating virgin T cells. As I understood
> from this latter model, apoptosis does not represent "danger". Is
> something wrong with the way I look at these models or is there a
> distinct discrepancy?
> Any suggestion?
>> Viggo VT
Ill have to go look at the paper about x-priming but5 from what i
understand polly matzingers hypothesis supports the idea that apoptotic
cells do not recruit or activate APC's since the regularly dying
apoptotic cells are not dangerous.
