In article <199901240107.RAA07488 at net.bio.net>, Jay and Nancy Mone
<URL:mailto:jaymone at PAONLINE.COM> wrote:
> To further confuse the issue, the route of inoculation is also important.
> Several antigens (e.g. pollens) induce IgE responses when inhaled, but
> IgG responses when injected.
>> Jay Mone'
>
There was a review some months back in Immunology Today from Farouk
Shakib's laboratory detailing their studies on some allergens in particular
Der p I where the allergen turns out to be a protease which cleaves
specific receptors off of the surface of B and T cells (eg the B-cell low
affinity IgE receptor) and thus reinforces a TH2 type of response.
Mike Clark, <URL:http://www.path.cam.ac.uk/~mrc7/>
--
o/ \\ // || ,_ o M.R. Clark, PhD. Division of Immunology
<\__,\\ // __o || / /\, Cambridge University, Dept. Pathology
"> || _`\<,_ // \\ \> | Tennis Court Rd., Cambridge CB2 1QP
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