HLA DPB1 LOCUS OF SPECIES

[ladasky at my-deja.com]

In article <199907181430.HAA17818 at net.bio.net>,
  hhl6 at 163.net wrote:
> Hi,everybody:
> we found a novel HLA-DPB1 allele in chinese population.I would like
> to compare it with correspondable locus of other species.
> Would you please tell me how can I get sequence of the Locus
> corresponding with HLA DPB1 from any other species such as
> DLA(dog),SLA(swine),RLA(rabbit),GpLA(guinea pig),H-2(mouse), AgBH-1 and
> B(chicken) ?
> I would appreciate it.

This is not trivial.  Class I and Class II MHC loci have arisen and
disappeared rapidly throughout evolutionary history.  Even within humans,
some populations that possess class II loci that others lack.  There may
be no homologous locus to DPB1 in other species.  If you go out as far as
the mouse and chicken, you have essentially no hope of recognizing a
homologous locus.  You will have an easier time recognizing a DPB1
homolog in very close relatives of humans, i.e., the other primates.
Even in these closely-related species, there will often not be enough
sequencing data to conclude definitively that a given locus is the
homolog you seek.

Still, with your credentials, I'm sure that you know how to read the
biomedical literature.  A Medline search (http://www.ncbi.nlm.nih.gov/
PubMed/) using the key words "nonhuman" and "DPB1" comes up with two
articles:

Otting N, et al. Characterization and distribution of Mhc-DPB1 alleles in
chimpanzee and rhesus macaque populations. Hum Immunol. 1998
Oct;59(10):656-64.

Gyllensten U, et al. Rapid allelic diversification and intensified
selection at antigen recognition sites of the Mhc class II DPB1 locus
during hominoid evolution. Tissue Antigens. 1996 Mar;47(3):212-21.

Clicking on the "see related articles" link reveals over a hundred more
papers, some of which may be of interest.

> Honglian Huang,Ph.D. and M.D.
> Department of Biochemistry
> School of Life Science
> Sun Yat-Sen University
> Guangzhou,510275
> P.R.China
> Tel:0086-020-84113655
> Fax:0086-020-84038377

--
John J. Ladasky Jr., Ph.D.
Department of Structural Biology
Stanford University Medical Center
Stanford, CA 94305
--


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