The danger of "Danger"

F. Frank LeFever flefever at
Mon Jun 7 21:46:26 EST 1999


Actually, I am perhaps more interested in inflammatory aspects of
immune activity than in immune activity per se.  My search (via Ovid CD
for past 4 yrs of Medline) turned up a lot of articles relating IL-1 to
apoptosis, but mostly in terms of IL-1 triggering apoptosis or
sometimes blocking it when triggered by other means, only 2 or 3
reported the reverse sequence, and I believe these were special cases:
apoptopic macrophages releasing stored IL-1.

Any refs to apoptosis of other cells triggering IL-1 production,
activation (cleavage by ICE?), and/or release involving other types of 

F. Frank LeFever, Ph.D.
New York Neuropsychology Group

In <7jf2lr$mbo$1 at> iayork at (Ian A. York)
>In article <7jclbk$bna at>,
>F. Frank LeFever <flefever at> wrote:
>>Admittedly, my knowledge of immunology is very limited, but I am
>>surprised to hear this about apoptopic cells.  Will this be an easy
>>subject to search for (e.g. "aptoptosis or apoptopic" AND "immune")? 
>>If not, can you cite some articles for me?
>J Immunol 1998 Nov 1;161(9):4467-71 
>Bystander apoptosis triggers dendritic cell maturation and
>antigen-presenting function.
>Rovere P, Vallinoto C, Bondanza A, Crosti MC, Rescigno M,
>Ricciardi-Castagnoli P, Rugarli C, Manfredi AA
>J Exp Med 1998 Oct 5;188(7):1359-68
>Immature dendritic cells phagocytose apoptotic cells via alphavbeta5
>CD36, and cross-present antigens to cytotoxic T lymphocytes.
>Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, Silverstein RL,
>Bhardwaj N
>Nature 1998 Mar 5;392(6671):86-9
>Dendritic cells acquire antigen from apoptotic cells and induce class
>I-restricted CTLs.
>Albert ML, Sauter B, Bhardwaj N
>to start with.
>    Ian York   (iayork at  <>
>    "-but as he was a York, I am rather inclined to suppose him a
>     very respectable Man." -Jane Austen, The History of England

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