B-cell activation

paul.fonteneau fonteno at pharma.u-strasbg.fr
Mon Jun 28 08:13:37 EST 1999


KJRKISHORE wrote:
> 
> In the following case how a B-Cell can act as a antigen presenting
> cell?
> 
> If we inject a pure protein ( assume that it is having 5 antigenic
> determinants )in to pure mice there will be an antigenic responce
> againest that protein.

YES, indeed...

 As we know that 5 different B-Cells come in
> to play againest that protin.

YES...

 My question is that which B-Cell
> takes in that protein. All the fice can not take in only one cell
> can do that. If that is the case which one do that?

All the five cells are able to take the protein... because when you say
ONE pure protein, it means many many many many many molécules of this
protein. It means that each B-cell can take at least 100 may be 2000
mçolécules of the same protein recognized  (or linked) by one epitope.
> 
> What I feel the  B-Cell which is attacking protein first binds with
> that and it induces tha conformational change in the protein and
> thereby it can prevent the engulfment from other B-Cells available
> nearby. 

Absolutly not !!!

Is it one of the possible answer or not?


See above


> My second question is why tissue specific antigens are not acting as
> antigens?


THEY DO... definitively...

Everything is an antigen, it's the definition of antigen...
because everything can be recognized by an BcR...



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