MHC haplotype

Dom Spinella dspinella at chugaibio.com
Tue Mar 2 15:10:25 EST 1999


> Hi everyone,
> 
> I would like to know if anyone knows the MHC haplotypes, or even better
> what type of MHC class I molecules for the NIH-3T3 cells. Will
> appreciate your response to hegden at ohsu.edu. Thanks.
> 
> Nag

The 3T3 line was developed in outbred NIH Swiss mice.  However, a
published study by Ivanyi in 1987 (Ivany1,D. Antigenic phenotype of NIH
3T3 cell line. J.Natl.Cancer.Inst. 79: 149-53; 1987) determined it to
have the H-2q haplotype (i.e. the q allele at H-2D, H-2K and H-2L Class
I loci).  Ah, it takes me back to those good old days of H-2 serology... 
Cheers. --Dom Spinella



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