Immune Response

Alec Redwood aredwood at cyllene.uwa.edu.au
Sun Mar 28 21:47:37 EST 1999


I answered direct but will answer here as well.  Apart perhaps from DNA
vaccines (don't know much about how these operate) I don't know of a
vaccination that doesn't cause some inflammation.  It would be a brave
person that sates the inflammatory reaction is not a component of the
immune response (Ag specific).  By the way humoral immunity is not the
only type of immunity.  However (except for polyvalent Ag) Ag even the
humoral immune response requires T-cells and T-cells (and B-cells in most
cases) require Ag presentation.  Ag is presented by APC (in the case of a
naive response) probably by dendritic cells.  Dendritic cells require some
signal of Danger (if you want P. Matzingers version) to become activated,
take up Ag and migrate to regional lymph nodes and on the way become
better at A presentation.  It is a fair bet that local inflammatory
responses facilitate this Ag up-take and migration.  So while the process
of APC presentation to T-cells (with MHC/TCR interaction and second signal
interaction) is not inflammation, the immune system resists the division
of different components of it's function into non overlapping functions.
Where does the inflammatory reaction finish and Ag specific events start.

Jay and Nancy Mone wrote:

> While some degree of inflammation always accompanies an injection,
> inflammation is in no way required for the development of immunity.
> Inflammation does augment immunity by attractong leukocytes to the area
> of inoculation, but the process of inducinga humoral immune response is
> an entirely different pathway.
>
> Jay Mone'




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