Replacement/Silent mutations in IgVH-genes!!!

Constanze Knörr conny.knoerr at mail.uni-wuerzburg.de
Tue Mar 30 06:20:06 EST 1999


>Has anyone experiences in the calculation of expected replacement
mutations in IgVH-genes? Itried it with the fomulars of Chang and Casali
(Immunology Today, 1994), but I do not know how I get the value for the
relative size of CDRs or FRs. I cannot recalculate the values given in
the paper!
Does anyone have the software for calculating the total possible
mutation in a given VH-gene, like in the paper from CHang and Casali!!!
Thanks for help!

Conny




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