Complement and Sheep Red Cells

Derek W.R. Gray derek.gray at nds.ox.ac.uk
Fri May 14 11:13:39 EST 1999


Has anyone any information on the difference between human plasma and
serum in terms of activation of the alternative pathway of
complement-mediated lysis of sheep red cells?  We are using this has a
positive control for another assay of the effect of complement (on
xeno-genetic islets), and have found that plasma has a remarkable
inability to lyse sheep red cells.  Is this on the basis of complement
inhibitors ?  I would suspect this is the sort of information that was
worked out many years back, I will be grateful if anyone can search
their memory for information or source of expertise.

Derek Gray



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