IgG - IgG interactionS...

F. Hayashi hayashi at u.washington.edu
Thu May 20 13:12:12 EST 1999

On Thu, 20 May 1999, Emmanuel- wrote:

> Anyone has some information on the nature of the interactions between IgG.
> I have seen papers describing Fab-Fab and Fab-Fc connections but not much
> details on the nature of these interactions unfortunately...
> Are these interactions really specific such as anti-antibody or anti-denatured antibody ?
> Is there a constitutive expression of anti-IgG in mammalian ?

Do you mean antibodies that are specific to other antibodies?

In that is the case, the interaction is the same as any antibody-antigen

Polyclonal antibodies raised in animals, such as those used as secondary
antibodies (like Goat anti-Rat IgG) are a mixture of antibodies that sees
all parts of the target antibody.

Monoclonal antibodies could be specific to any part of the target
antibody, depending on what you screen with.

If you mean other kinds of interactions....

Fab is of course covalently linked to the Fc portion.
Fc portions of some Ig isotypes interact to form multimers (IgM, IgA)

anything else I missed?

| Fumitaka Hayashi      -       hayashi at u.washington.edu      |
| http://macrophage.immunol.washington.edu/~fumi/index.html   |
| Aderem Lab - Dept. of Immunology - University of Washington |

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