IUBio

IgG - IgG interactionS...

Mike Clark mrc7 at cam.ac.uk
Fri May 21 06:51:23 EST 1999


In article <3743CE48.4FDB1297 at fccc.edu>, Greg Adams
<URL:mailto:gp_adams at fccc.edu> wrote:
> Antibodies that react to the antigen binding domain (CDRs) of another
> antibody are typically called anti-idiotype antibodies.  This occurs
> naturally in people and a chain reaction type of effect can occur with
> the antibody (#2) that binds to the antigen binding domain of the first
> antibody (#1), mimicing the original antigen target of the first
> antibody.  The second antibody then can actually initiate an immune
> response that will recognize the original antigen.  Similar strategies
> are being employed in clinical trials to try to stimulate patients to
> mount an immune response to tumor antigens.

Only a subset of potential anti-idiotypes are likely to mimic an
alternative antigen for the first antibody. Equally not all anti-idiotypes
to the anti-idiotype are likely to be identical to the starting antigen.

Think of it like this. Antibodies do not have a unique reactivity with a
single antigen. They are likely to cross react with a potentially large
number of antigens but with differing affinities for each antigen. Some
reactivities will be very low and go unobserved others may be higher and
detectable. Now in the case of idiotype and anti-idiotype they are both
antibodies and antigens at the same time so for antigen above substitute
antibody. ie each antibody potentially reacts with a large number of
different anti-idiotype antibodies but with different affinities. Now would
you claim that each of these antibodies is a mimic of all the others?

Mike Clark,                        <URL:http://www.path.cam.ac.uk/~mrc7/>
-- 
 o/ \\    //            ||  ,_ o   M.R. Clark, PhD. Division of Immunology
<\__,\\  //   __o       || /  /\,  Cambridge University, Dept. Pathology
 ">    ||   _`\<,_    //  \\ \> |  Tennis Court Rd., Cambridge CB2 1QP
  `    ||  (_)/ (_)  //    \\ \_   Tel.+44 1223 333705  Fax.+44 1223 333875




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