Mike Clark mrc7 at cam.ac.uk
Wed May 26 10:52:49 EST 1999

In article <374EA48E.3176FFA6 at zsu.edu.cn>, anlong xu
<URL:mailto:ls36 at ZSU.EDU.CN> wrote:
> 1-10% T cells can directly recognize the alloantigen, which is not
> self-MHC restricted. It seems to be controversial to the classical T
> cell recognition model of self-MHC restricted
> One explanation is that allo-MHC molecule mimic the structure of
> self-MHC and peptide complex. Is there any experiment verify this
> hypothesis?
> I would like to discuss with you.
> Thank you for your consideration

I'm in the middle of examining so haven't time to  pull out any of the
references but the explanation is as you say

allo-MHC plus peptide Y is seen by the same receptor as self MHC plus
peptide X. In some circumstances X and Y could be the same peptide but more
often they are not.

The other important thing to remember is that a single TCR may be able to
recognise several different MHC-peptide complexes even in the same host.


Mike Clark,                        <URL:http://www.path.cam.ac.uk/~mrc7/>
 o/ \\    //            ||  ,_ o   M.R. Clark, PhD. Division of Immunology
<\__,\\  //   __o       || /  /\,  Cambridge University, Dept. Pathology
 ">    ||   _`\<,_    //  \\ \> |  Tennis Court Rd., Cambridge CB2 1QP
  `    ||  (_)/ (_)  //    \\ \_   Tel.+44 1223 333705  Fax.+44 1223 333875

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