T-cells populations when thymus non-functional

paul.fonteneau fonteno at pharma.u-strasbg.fr
Thu Oct 14 04:54:39 EST 1999


vborde at my-deja.com wrote:
> 
> Hello everyone
> I would like to know what would happen to the
> T-cells population (repertoire) when the thymus
> becomes non-functional, at the adult phase? Would
> this person lose all his mature T-cells? Would he
> also lose his self tolerance and become velnerable
> to autoimmune disease? How are the T-cells
> renewed? Thank you very much.


It's probably the subject of the next Nobel's prize ;=))
In fact, nobody knows what happens in this case.
It seems that some mature, educated T-cells could survive for a very
long time in the periphery.
Another hypothesis says that they could have the ability of
self-renewing... 
The last hypothesis explains that may be there is another place for
T-cells to be educated (skin ? epithelia ??)

But all the observations which are made show that older persons are more
sensitive to autoimmune disease...



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