Anti-MHC-peptide complex antibodies??

ladasky at my-deja.com ladasky at my-deja.com
Thu Sep 30 02:42:28 EST 1999


In article <Pine.OSF.3.91.990929165822.20662A-100000 at imtech.ernet.in>,
  nsharma at IMTECH.ERNET.IN (Naresh Sharma) wrote:
> Has anybody raised antibodies against MHC-peptide complex ?
> reply to
>
> naresh76 at bigfoot.com

There are many anti-MHC antibodies that recognize MHC complexed with
peptide.

Or do you mean to ask whether there are antibodies against *specific*
peptides bound to *specific* MHC molecules?  Well, no, there are none of
those.  There are a few antibodies which recognize portions of the alpha
helices plus an amino acid or two of the peptide, but that's as specific
as they get.

--
John J. Ladasky Jr., Ph.D.
Department of Structural Biology
Stanford University Medical Center
Stanford, CA 94305
--


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