Anti-MHC-peptide complex antibodies??

Schiffer schiffp at my-deja.com
Thu Sep 30 12:33:47 EST 1999


In article <7t069a$agf$1 at nnrp1.deja.com>,
  Schiffer <schiffp at my-deja.com> wrote:
> In article <Pine.OSF.3.91.990929165822.20662A-100000 at imtech.ernet.in>,
>   nsharma at IMTECH.ERNET.IN (Naresh Sharma) wrote:
> > Has anybody raised antibodies against MHC-peptide complex ?
> > reply to
> >
>
> The June 1997 issue of Immunity describes 2 anti-MHC/ peptide mAb.
>
> Localization, Quantitation, and In Situ Detection of Specific Peptide–
> MHC Class I Complexes Using a Monoclonal Antibody
> Angel Porgador, Jonathan W. Yewdell, Yuping Deng, Jack R. Bennink, and
> Ronald N. Germain
>
> Characterization and Quantitation of Peptide–MHC Complexes Produced
> from Hen Egg Lysozyme Using a Monoclonal Antibody
> Gilles Dadaglio, Christopher A. Nelson, M. Brian Deck, Shirley J.
> Petzold, and Emil R. Unanue
>
> Porgador's Ab is against Kb/SIINFEKL (Ovalbumin residues 257-264) that
> has been used quite extensively by other investigators.  There was
also
> one generated by phage display that is specific for an Influenza
> Hemeagglutinin peptide in the context of Kk.  This was reported in
PNAS
> around the time of the others.

Andersen, P. S., Stryhn, A., Hansen, B. E., Fugger, L., Engberg, J. &
Buus, S. (1996) Proc. Natl. Acad. Sci. USA 93, 1820-1824

--
P. Schiff


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