Neural antigen presentation in Multiple sclerosis

Theophilus Samuels theophilus.samuels at
Sat Apr 22 06:46:33 EST 2000

One of the main general factors in establishing peripheral tolerance is the
form of the antigen and its route of administration. In the case of MS, why
would the T cells become tolerant to something which they should/would never
normally come into contact with? Fascinatingly, if you read the article by
Oksenburg et al. in Sem Neurology 19(3):281-288 1999, they write that the
MHC complex gene on chromosome 6p21 is the only MS susceptibility gene that
generates significant linkage. Fascinating that in this context, this gene
also happens to be related to the antigen presentating processes that occur
in every single one of us.


Anastas Pashov <ibir at> wrote in message
news:39016CA3.8BFB93F0 at
> I thought that when discussing the reactivity to neural antigen in MS
> one should consider rather the mechanisms of peripheral tolerance
> involving regulatory T cells in the lymphatics where the activation
> takes place instead of focusing on the stimulating antigen that may well
> be a crossreacting viral or bacterial antigen.
> Anastas
> ---

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