Neural antigen presentation in Multiple sclerosis

Theophilus Samuels theophilus.samuels at
Sun Apr 23 05:19:22 EST 2000

>From the Experimental Biology 2000 meeting;

'...Dr. Popovich and colleagues stimulated T cells with myelin proteins and
injected them into animals with spinal cord injury. The treatment
significantly improved hind limb function, according to Dr. Popovich.

"Traditionally we've always thought of a T cell responding to nervous system
proteins as being bad," he said. "It's mostly because the methodology and
the models have been developed in the context of multiple sclerosis, which
is where T cells are typically causing damage. It's the context in which the
cells become activated that may dictate whether it's a protective or
detrimental effect."

Although these monocyte- and T cell-based treatments increased hind limb
function only by 10%, the researchers noted that this is comparable to the
effects of methylprednisolone, the current standard of therapy for spinal
cord injury in humans...'


Theophilus Samuels <theophilus.samuels at> wrote in message
news:8ds3ec$iqu$1 at
> One of the main general factors in establishing peripheral tolerance is
> form of the antigen and its route of administration. In the case of MS,
> would the T cells become tolerant to something which they should/would
> normally come into contact with? Fascinatingly, if you read the article by
> Oksenburg et al. in Sem Neurology 19(3):281-288 1999, they write that the
> MHC complex gene on chromosome 6p21 is the only MS susceptibility gene
> generates significant linkage. Fascinating that in this context, this gene
> also happens to be related to the antigen presentating processes that
> in every single one of us.
>   T.L.S
> Anastas Pashov <ibir at> wrote in message
> news:39016CA3.8BFB93F0 at
> > I thought that when discussing the reactivity to neural antigen in MS
> > one should consider rather the mechanisms of peripheral tolerance
> > involving regulatory T cells in the lymphatics where the activation
> > takes place instead of focusing on the stimulating antigen that may well
> > be a crossreacting viral or bacterial antigen.
> >
> > Anastas
> >
> > ---

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