Unique Structural Biology opportunities for Biochemists

Focco Van Den Akker vandenf at ccf.org
Tue Dec 5 10:22:12 EST 2000


A research technician position is available immediately to assist 
in molecular biology and protein expression/purification efforts for 
protein crystallography purposes. Applicants should have experience in 
molecular biology and/or protein expression/purification. The lab
is well equipped with the tools for bacterial, yeast, and mammalian cell
culture protein expression. In addition, we have BIOCAD Sprint, FPLC, 
and AKTA-FPLC purification systems.   
This position offers also a unique opportunity to learn new state-of-
the-art structural biology techniques such as crystallization, 
data-collection and more if interested.

In addition, post-doctoral opportunities for biochemists who have 
an interest in structural biology are available as well. The successful 
applicants will join a strong and internationally recognized Structural 
Biology  Center (see van den Akker et al. Nature 406, 101-104, 2000) that 
is aiming to be at the forefront in this genomics age of research. 
The aim of the project in the lab is to elucidate the molecular mechanism 
of several guanylyl cyclase coupled receptors which are involved in a 
variety of physiological processes such as blood pressure regulation and 
photo adaptation in cones and rods.
The successful candidate should have experience with handling proteins
in particular their over-expression and purification. The applicant
should also have an interest in structural biology and a desire to 
learn protein crystallography but experience is not required. 
Our laboratories are located in state-of-the-art facilities in the Lerner 
Research Institute and are fully equipped for E. coli, yeast, and 
mammalian cell protein expression, protein purification, X-ray diffraction
and computation.  For more information about our research please visit our 
website: www.lerner.ccf.org/labs/yee/    

The Lerner Research Institute of the Cleveland Clinic Foundation provides 
a top notch biomedical as well as basic research environment and ranks # 7 
among non-profit research institutes in the USA for attracting NIH funding. 
Cleveland itself was recently ranked among the top 4 most livable cities 
in the US by Partners for Livable Communities.

Please send c.v., list of three references, and cover letter to Dr. Focco 
van den Akker, Center for Structural Biology/NB20, Lerner Research Institute, 
Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.  
Email: vandenf at ccf.org . 
Tel: 216-444-3588; Fax: 216-445-1466
The Cleveland Clinic Foundation is an Equal Opportunity/Affirmative Action 


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