secretion mechanism of IgG

Mike Clark mrc7 at cam.ac.uk
Fri Jun 30 12:29:25 EST 2000


In article <8ji4st$4kj$1 at nnrp1.deja.com>, <URL:mailto:mlindow at my-deja.com>
wrote:
> Hi group,
> 
> Do any of you know or have good references to the mechanisms of
> immunoglobulin secretion from plasma cells? Do they have the usual
> signalpeptides that are cleaved off?
> 
> Regards,
> 
> Morten Lindow
> LAb Molecular Pharmacology
> Copenhagen Uni.
> Denmark
> 

I think if you go back to the very early publications of Cesar Milstein
(I believe the reference I recall was coauthored by George Brownlee) you
will find one of the earliest descriptions of a signal peptide. The protein
they were working on at the time was IgG.

Mike Clark,                        <URL:http://www.path.cam.ac.uk/~mrc7/>
-- 
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