Boosting protein immunisation lowers Ab response
jchandler at mainebiotechnology.com
Thu Mar 2 11:55:42 EST 2000
Here is a thought.
What was the time frame between the second two boosts? If it was less than
three weeks, it is possible that the amount of circulating antigen-specific
Ig was high enough to form antigen-antibody complexes clearing most of your
immunogen out of the system. This would results in a reducing the actual
amount of immunogen left to stimulate the immune system to quite a bit less
than you might expect.
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