Boosting protein immunisation lowers Ab response

Joe Chandler jchandler at
Thu Mar 2 11:55:42 EST 2000

Here is a thought.
What was the time frame between the second two boosts?  If it was less than
three weeks, it is possible that the amount of circulating antigen-specific
Ig was high enough to form antigen-antibody complexes clearing most of your
immunogen out of the system.  This would results in a reducing the actual
amount of immunogen left to stimulate the immune system to quite a bit less
than you might expect.

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