activation

Doug Neubauer dougnbr at earthlink.net
Fri Apr 6 18:21:38 EST 2001


In article <3ACC996B.CE408820 at Mail.TJU.Edu>, Mark.Haynes at Mail.TJU.Edu wrote:
>Hello all,
>I am looking for information about secondary markers (cd28, ctla4,
>cd40l) on human T cells.  I want to know what differences there are
>between virgin and non-virgin T's regarding expression.  I know that
>ctla4 is low to negligible unless the cell is stimulated and I plan to
>compare un-stimulated to anti-cd3 stimulated but I don't know about the
>other molecules.
>If someone could send refs or point me to the answers I would be
>grateful
>thanx
>markH.
>I
>

Not sure if this is what you're looking for,  here are some articles
on phenotype/function vs. naive/effector/memory t cells:

Functional differences between memory and naive CD8 T cells.,
Cho, et al., Proc Natl Acad Sci USA 1999 Mar 16;96(6):2976-81 (PMID:10077622)

T cell memory: heterogeneity and mechanisms.,
Farber, Clin Immunol 2000 Jun;95(3):173-81 (PMID:10866123)

Dynamics and requirements of T cell clonal expansion in vivo at the...,
Gudmundsdottir, et al., J Immunol 1999 May 1;162(9):5212-23 (PMID:10227995)

Phenotypic and functional separation of memory and effector human CD8+ T...,
Hamann, et al., J Exp Med 1997 Nov 3;186(9):1407-18 (PMID:9348298)

Differentiation of naive CTL to effector and memory CTL: correlation of...,
Oehen, BrduschaRiem, J Immunol 1998 Nov 15;161(10):5338-46. (PMID:9820507)

Regards,

Doug

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