inflammatory response

wayne conlan wayne.conlan at nrc.ca
Thu Apr 12 15:06:23 EST 2001

To some extent the dynamics of the inflammatory response will be bug specific.
Some bugs fail to trigger certain proinflammatory stimuli as a means of avoiding
the immune system. Moreover, the sequence of events will vary depending on
whether you're dealing with an intracellular or extracellular pathogen.



Frederic Langlois wrote:

> Hello! I'd like to know what triggers the inflammatory response when a
> bacteria infects an host. I'm trying to figure out the order the host and
> the immune system respond.
> Which system is triggered first? Is it the alternative complement pathway? I
> know the coagulation, the kinins and the fibrinolysis enzymes are involved.
> How do they interact with each other?
> I'm writing a popularized scientific paper (20 pages) on anti-bacterial
> immunity. From this point of view I should consider the complement as the
> first system to ring the alarm when infection occurs, right?
> The 23 manuals I've read so far are all describing each individual
> sub-system of the host's response to infection, but none of them clearly
> answered these questions.
> TIA,
> Frederic Langlois

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