H-2b T Helper epitopes
Kenneth A Frauwirth
kfrauwir at mail.med.upenn.edu
Wed Sep 26 14:21:56 EST 2001
On Fri, 21 Sep 2001 20:42:37 +0100, Simon Frost
<Frostie.Football at btinternet.com> wrote:
> I am interested in using H-2b restricted helper epitopes in a mouse
>model. Is there database of epitopes in existence, or are any characterised
>for OVA and HEL.
I don't know about an epitope database, but there are at least a few
characterized H-2b helper epitopes. Probably the best-studied is the Y-Ae
epitope, in which a peptide from the I-E-alpha chain is presented in A(b).
In addition, HEL(74-88)/A(b) is recognized by the T cell hybridoma BO4H9
(see Karttunen and Shastri, PNAS 88:3972). There is also an invariant
chain epitope (CLIP) that can be presented on A(b) to the T cell hybridoma
24-2 (Morkowski et al., JEM 182:1403).
I hope this helps,
Ken Frauwirth (MiSTie #33025) kfrauwir at mail.med.upenn.edu
Abramson Cancer Research Institute
University of Pennsylvania
"Science is not the way to find the answers to all of our questions.
Science is a way to find better questions." - C. Barrans
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