H-2b T Helper epitopes

Kenneth A Frauwirth kfrauwir at mail.med.upenn.edu
Wed Sep 26 14:21:56 EST 2001

On Fri, 21 Sep 2001 20:42:37 +0100, Simon Frost 
<Frostie.Football at btinternet.com> wrote:
>    I am interested in using H-2b restricted helper epitopes in  a mouse
>model. Is there database of epitopes in existence, or are any characterised
>for OVA and HEL.

I don't know about an epitope database, but there are at least a few 
characterized H-2b helper epitopes.  Probably the best-studied is the Y-Ae 
epitope, in which a peptide from the I-E-alpha chain is presented in A(b).  
In addition, HEL(74-88)/A(b) is recognized by the T cell hybridoma BO4H9 
(see Karttunen and Shastri, PNAS 88:3972).  There is also an invariant 
chain epitope (CLIP) that can be presented on A(b) to the T cell hybridoma 
24-2 (Morkowski et al., JEM 182:1403).

I hope this helps,

Ken Frauwirth

Ken Frauwirth  (MiSTie #33025)   kfrauwir at mail.med.upenn.edu
Abramson Cancer Research Institute
University of Pennsylvania
"Science is not the way to find the answers to all of our questions.
 Science is a way to find better questions." - C. Barrans

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