how does the body tell an exogeneous peptides from endogeneous peptides

jeff frelinger jfrelin at med.unc.edu
Fri Aug 23 15:01:40 EST 2002


The body doesn't know.

Dogma is endogenous proteins from the cytosol go to the ER via TAP
load on class I

exogenous proteins are degraded in endosomes et al end up in MIIC and get
loaded onto class II.

Both there is considerable cross talk- i.e. cross presentation

Responses to the peptides are on the T cell side/ deletion/anergy/ignorance.

"chenhong" <chz155 at mail.usask.ca> wrote in message
news:2a79bee4.0208230837.4be34f19 at posting.google.com...
> Hi all,
>
> I have a basic immunology question to consult: how does the body tell
> exogeneous peptides from endogeneous peptides.
>
> I am guessing endogeneous peptides go through some modification
> process after they are synthesized. But if people know the structure
> and composition of an endogeneous peptide, then we can synthesize
> exactly such a peptide in vitro. Then how does the immune system tell
> where does this peptide come from. My second guess (wild) will be that
> the cell knows this by recalling if this peptide is swallowed or
> produced by itself.
>
> As you can see, I need more professional people to help me out here.
> Thanks for any help you can give me.
>
> Chenhong





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