Do dendritic cells move around?

Gordon MacPherson gordon.macpherson at path.ox.ac.uk
Thu Dec 19 08:40:21 EST 2002


DC are continually entering tissues as precursors from the blood.  In most
tissues e.g. respiratory tract, gut, they spend only a few days before migrating
via lymph to draining nodes.  Despite what many athorities suggest, they do this
continually in the absence of any inflammatory or "danger" stimulus.  They are
continually transporting self Ag for presentation to T cells and this very
probably plays an importan part in self tolerance.

Gordon MacPherson

"John H." wrote:

> I have read that microglia can differentiate into either a macrophage like
> cell or a DC cell. Different CSFs is the key I think. I have also noted refs
> that DCs can take up long term residence in the meninges and CNS. What I'm
> confused about is whether or not those DCs in the CNS will also migrate upon
> stimulation.
>
> John H.
>
> "Dan Marquez" <dmarquez3 at socal.rr.com> wrote in message
> news:AA3M9.151067$%k2.39644340 at twister.socal.rr.com...
> >
> >
> > "Dan Marquez" <dmarquez3 at socal.rr.com> wrote in
> >
> > > "When TNF, secreted by battling macrophages, binds to receptors on the
> > > surface of the dendritic cell, phagocytosis ceases, and the CD leaves
> the
> > > tissues and migrates through the lymphatic system to the nearest lymph
> > > node."
> >
> >
> > Did I type CD?  I meant to type DC! I've been spending too much time on my
> > computer!
> >
> > A good friend of mine brought up a interesting thought... could DC's and
> > macrophages really be the same?
> >
> >
> > Dan
> >
> >




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