Do dendritic cells move around?

John H. johnh at faraway.xxx
Thu Dec 19 12:51:01 EST 2002


Thanks Gordon, and noted below just now ... . Unfortunately the CNS is an
unusual case, generic references to DCs aren't going to do the job for me
but you've given me another angle to work on.

John H.

http://www.nature.com/cgi-taf/DynaPage.taf?file=/nri/journal/v2/n12/full/nri
974_fs.html

Nature Reviews Immunology 2, 905 (2002); doi:10.1038/nri974


DCs on the beat

Jennifer Bell

Dendritic cells (DCs) have long been recognized as the body's sentinels, but
evidence is emerging that they are responsible also for policing the immune
system. It has been proposed that DCs are 'on the beat' constantly,
ingesting tissue-associated antigens and presenting them in local lymph
nodes. In the absence of inflammation, this should result in the elimination
of potentially harmful self-reactive T cells. Three papers in a recent issue
of The Journal of Experimental Medicine provide further support for this
model and indicate that CD8+ DCs might be specialized ...


"Gordon MacPherson" <gordon.macpherson at path.ox.ac.uk> wrote in message
news:3E01CC45.E7283C21 at path.ox.ac.uk...
> DC are continually entering tissues as precursors from the blood.  In most
> tissues e.g. respiratory tract, gut, they spend only a few days before
migrating
> via lymph to draining nodes.  Despite what many athorities suggest, they
do this
> continually in the absence of any inflammatory or "danger" stimulus.  They
are
> continually transporting self Ag for presentation to T cells and this very
> probably plays an importan part in self tolerance.
>
> Gordon MacPherson
>
> "John H." wrote:
>
> > I have read that microglia can differentiate into either a macrophage
like
> > cell or a DC cell. Different CSFs is the key I think. I have also noted
refs
> > that DCs can take up long term residence in the meninges and CNS. What
I'm
> > confused about is whether or not those DCs in the CNS will also migrate
upon
> > stimulation.
> >
> > John H.
> >
> > "Dan Marquez" <dmarquez3 at socal.rr.com> wrote in message
> > news:AA3M9.151067$%k2.39644340 at twister.socal.rr.com...
> > >
> > >
> > > "Dan Marquez" <dmarquez3 at socal.rr.com> wrote in
> > >
> > > > "When TNF, secreted by battling macrophages, binds to receptors on
the
> > > > surface of the dendritic cell, phagocytosis ceases, and the CD
leaves
> > the
> > > > tissues and migrates through the lymphatic system to the nearest
lymph
> > > > node."
> > >
> > >
> > > Did I type CD?  I meant to type DC! I've been spending too much time
on my
> > > computer!
> > >
> > > A good friend of mine brought up a interesting thought... could DC's
and
> > > macrophages really be the same?
> > >
> > >
> > > Dan
> > >
> > >
>





More information about the Immuno mailing list