Do dendritic cells move around?

Dan Marquez dmarquez3 at socal.rr.com
Thu Dec 19 17:36:48 EST 2002


"Gordon MacPherson" <gordon.macpherson at path.ox.ac.uk> wrote in message
news:3E01CC45.E7283C21 at path.ox.ac.uk...
> DC are continually entering tissues as precursors from the blood.  In most
> tissues e.g. respiratory tract, gut, they spend only a few days before
migrating
> via lymph to draining nodes.  Despite what many athorities suggest, they
do this
> continually in the absence of any inflammatory or "danger" stimulus.  They
are
> continually transporting self Ag for presentation to T cells and this very
> probably plays an importan part in self tolerance.
>
> Gordon MacPherson
>

This is really very interesting!  Do macrophages also present self-Ag to Th
cells?

Dan





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