Nude mouse and lymphocytes.
mrc7 at cam.ac.uk
Thu Jul 11 06:00:16 EST 2002
In article <b5023d22.0207110253.a566025 at posting.google.com>, Gary
<URL:mailto:cool_and_funky at yahoo.com> wrote:
> Does anyone have any idea how the nude mouse compares in terms of the
> number of lymphocytes one would expect to see in its blood? I'm aware
> that the nude mouse is for all intents and purposes athymic, meaning
> that there is a lack of immunologically mature lymphocytes and a loss
> of ability to recognise non-self cells, but does this mean that there
> would actually be a decreased overall number of lymphocytes in the
> bloodstream, or would there be an equivalent number of cells (compared
> to a immunocompetent mouse) but these cells would be effectively
> unable to elicit an immune response?
> It'd be interesting to know, as I've not managed to find anyone so far
> that can confidently answer this.
My understanding is that nude mice (nu/nu) still possess NK cells. These
are "large granular lymphocytes" and will carry some of the same cell
surface markers as T or B- lymphocytes.
M.R. Clark, PhD. Division of Immunology
Cambridge University, Dept. Pathology
Tennis Court Rd., Cambridge CB2 1QP
Tel.+44 1223 333705 Fax.+44 1223 333875
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