"Daniele Focosi" <mi at interhealth.info> wrote in message
news:e794ccc8.0209200111.651152c2 at posting.google.com...
> Hi Dan,
> please visit www.mi.interhealth.info for a far more detailed
> explanation on existing types of regulatory T cells, including those
> with suppressor activity (use CTRL+F search method). Luciana's reply
> is almost partial, and most of your considerations on their ontogeny
> are wrong.
> After careful reading, please feel free to contact me for any
> additional question.
> The text is based on some recent reviews appeared on Nature Reviews
> Immunology : searching in PubMed is quite useless if you can't access
> full-texts (I had already experienced it !).
> Have a nice navigation !
>> Daniele
>> "Dan Marquez" <dmarquez3 at socal.rr.com> wrote in message
news:<xR9i9.17210$V7.4321913 at twister.socal.rr.com>...
> > Thank you kindly, Luciana! That was an old question, but the answer is
> > really appreciated nevertheless!
> >
> > Would it be correct to say that Suppressor T cells are the same helper T
> > cells that were outputting IL-4 (to proliferate more Th cells), their
> > function change resulting from a drop in IL-12 levels (because
macrophages
> > stopped eating)?
> >
> > Thanks!
Thank you, Daniele! Awesome input! Nice name too... kind of reminds me of
my name... Daniel! You are right about the PubMed publications. I do not
have an account to order the publications. I hate to see what they cost!
I did find http://www.mi.interhealth.info very interesting... wow! Lots of
details! I bookmarked it!
Unfortunately, I'm not a cytokine expert so I am challenged to "see the
forest from the trees." I did see...
1) CD4+25+ T suppressor cell are called "naturally occurring suppressor
cells".
2) They make up 10% total CD4+ T cells.
3) The origin of CD4+25+ suppressor T cells is unknown since they "Probably
they arise in thymus..."
This brings up a few interesting questions. I hope this isn't a bombardment
of questions; I can tell you're busy! Here they are...
1a) Would the CD4+25+ T cells still exist in a vitro solution that is rich
in IL-12 (the interleukin APC's secrete to indicate they just ate)?
1b) Or would CD4+25+ T cells merely be inhibited from suppressing?
1c) Can a solution that lacks IL-12 cause 25+ receptors to become expressed
on a percentage of non-suppressor T cells?
2) Do adult patients who lost their thymus well after their childhood years
have CD4+25+ T cells? (They must have suppressor T's of some kind, I would
think.)
3) What does CD mean?
4) Would your answers to above questions also apply to CD4+25-45RC- cells?
5) What does the pink "L" superscript mean?
Thanks in advance! FYI, I am not an immunologist by profession, so if I
seem naive... you know why. However, in an effort to relieve stress from my
real profession, I wrote an immunology booklette (yet unpublished) for
laymen. I did my best at simplifying concepts, like calling certain
selectins traffic signs that say, "Neutrophils must slow down." I'd be
happy to send you a doc file at your request.
Finding the origin of suppressor T cells has been a big challenge given my
limited resources.
Daniel
