A Question About Suppressor T Cells...

Daniele Focosi mi at interhealth.info
Sat Sep 21 06:53:48 EST 2002

1) I'm not sure, but I suppose yes.
2) I don't know.
3) CD means cluster of differentiation or cluster determinant
4) I don't know
5) the pink "L" superscript indicates a link to a local page (ie
created by myself), according to ExPASy's conventions.
Try post unanswered question in another thread and let other try to
answer you : I'm just a PhD student and you may be sure I don't know
many things on immunology!
Please send me your .doc booklet: I'll read it carefully.
With best regards,


"Dan Marquez" <dmarquez3 at socal.rr.com> wrote in message news:<4CKi9.20073$V7.6115531 at twister.socal.rr.com>...
> "Daniele Focosi" <mi at interhealth.info> wrote in message
> news:e794ccc8.0209200111.651152c2 at posting.google.com...
> > Hi Dan,
> > please visit www.mi.interhealth.info for a far more detailed
> > explanation on existing types of regulatory T cells, including those
> > with suppressor activity (use CTRL+F search method). Luciana's reply
> > is almost partial, and most of your considerations on their ontogeny
> > are wrong.
> > After careful reading, please feel free to contact me for any
> > additional question.
> > The text is based on some recent reviews appeared on Nature Reviews
> > Immunology : searching in PubMed is quite useless if you can't access
> > full-texts (I had already experienced it !).
> > Have a nice navigation !
> >
> > Daniele
> >
> > "Dan Marquez" <dmarquez3 at socal.rr.com> wrote in message
>  news:<xR9i9.17210$V7.4321913 at twister.socal.rr.com>...
> > > Thank you kindly, Luciana!  That was an old question, but the answer is
> > > really appreciated nevertheless!
> > >
> > > Would it be correct to say that Suppressor T cells are the same helper T
> > > cells that were outputting IL-4 (to proliferate more Th cells), their
> > > function change resulting from a drop in IL-12 levels (because
>  macrophages
> > > stopped eating)?
> > >
> > > Thanks!
> Thank you, Daniele!  Awesome input!  Nice name too... kind of reminds me of
> my name... Daniel! You are right about the PubMed publications. I do not
> have an account to order the publications. I hate to see what they cost!
> I did find http://www.mi.interhealth.info very interesting... wow!  Lots of
> details!  I bookmarked it!
> Unfortunately, I'm not a cytokine expert so I am challenged to "see the
> forest from the trees." I did see...
> 1) CD4+25+ T suppressor cell are called "naturally occurring suppressor
> cells".
> 2) They make up 10% total CD4+ T cells.
> 3) The origin of CD4+25+ suppressor T cells is unknown since they "Probably
> they arise in thymus..."
> This brings up a few interesting questions. I hope this isn't a bombardment
> of questions; I can tell you're busy! Here they are...
> 1a) Would the CD4+25+ T cells still exist in a vitro solution that is rich
> in IL-12 (the interleukin APC's secrete to indicate they just ate)?
> 1b) Or would CD4+25+ T cells merely be inhibited from suppressing?
> 1c) Can a solution that lacks IL-12 cause 25+ receptors to become expressed
> on a percentage of non-suppressor T cells?
> 2) Do adult patients who lost their thymus well after their childhood years
> have CD4+25+ T cells? (They must have suppressor T's of some kind, I would
> think.)
> 3) What does CD mean?
> 4) Would your answers to above questions also apply to CD4+25-45RC- cells?
> 5) What does the pink "L" superscript mean?
> Thanks in advance!  FYI, I am not an immunologist by profession, so if I
> seem naive... you know why.  However, in an effort to relieve stress from my
> real profession, I wrote an immunology booklette (yet unpublished) for
> laymen.  I did my best at simplifying concepts, like calling certain
> selectins traffic signs that say, "Neutrophils must slow down."  I'd be
> happy to send you a doc file at your request.
> Finding the origin of suppressor T cells has been a big challenge given my
> limited resources.
> Daniel

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