Innate immunity

Geronimo user at
Mon Feb 17 09:13:28 EST 2003

I would also say your question is very interesting, thought for a different
reason. I agree with Mike that AB-based immune responses fall, by
definition, in the 'adaptive' class. I don't think there is ever an
'adaptive' response without an 'innate' response as well.

The ABO antigen example highlights one of the many inconsistencies in
Immunology. Although one could argue that anti-ABO ABs are expressed for
some reason in every individual, the current paradigm cannot explain why, in
case of a blood transfusion with an incompatible blood type, the immune
response has the characteristics of a secondary rather than a primary
response. Unless the same antigens are present in some very common
pathogens, but that remains to be shown.

<idv at> wrote in message
news:20030217111256.10643.qmail at
> Is always the innate immunity response an antibodie independent
response?for example, in ABO incompatible kidney transplant you have
anti-blood group antibodies preformed and you have an immune response. What
kind of response?¿adquired or innate?

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