Antibody's specifity...

Mr. Hat misterhat at sbcglobal.net
Mon Jul 21 22:33:12 EST 2003


In article <BB418BCF.96C%nikolai.scherbak at nat.oru.se>,
nikolai.scherbak at nat.oru.se (Nikolai Scherbak) wrote:

> Dear colleagues!
> Can antibodies raised against one protein bind also to another protein with
> the 50% similarity to the first one?
> 
> Sincerely, Nikolai
> 
> ---

Well obviously you would need information regarding what part of the first
protein the Ab "maps" to, as well as 3D structure (since odds are it will
be a conformational rather than linear epitope), and then *maybe* you can
decide...based on structure of the second protein and whether or not the
epitope region is among the 50% conserved...the same Ab will bind.

Short response: you'll have to try and see. It is impossible to answer
your question based solely upon the information provided.

best,
M.H.



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