Mechanism for Nutrient Transport

Dan Marquez dmarquez3 at
Mon Mar 24 13:38:22 EST 2003

Thank you Mikael.

Here is my responcse..

> The transporters that absorb the nutrients are proteins that are
> synthesized in the cells lining the small intestine and they reside in
> those cells membrane.

I will interpret that "cells lining the small intestine"  are specialized
cells that make the intestine. They would not be the blood cells, for

> Chylomicrones is only made in the cells lining the small intestine,
> and it’s always secreted into the lymph.

That is really good to know. Interestingly, it seems as though your
apostrophes were somehow converted to ’ when you posted your
response... at least on my PC.  There's a new puzzle.

> I tried too look a little bit into Chron’s, but it seem that
> none is really shore about the causes of the deasese. But it seems too
> be a lot of research in the field and it look like many investigators
> are thinking that it could bee bacterial caused.

Crohn's research is interesting.  While bacteria  (especially MAP) could be
a cause of Crohn's, there are some interesting observations I found...

1) People who have damaged their abdomens (such as from car accidents) often
develop symptoms similar to Crohn's as well as food allergies.

2) Remission is possible when steps are taken to break down foods to smaller
sizes before consumption... including juicing vegetables, chewing more,
eating less, blending foods, consuming digestive enzymes, consuming
probiotics, and even swallowing worm eggs that hatch in the gut!

3) Crohn's get's worse when food is broken down less before reaching the
ileum. Thus, eating large meals, eating hard-to-digest foods, etc. will
worsen Chrohn's.  Even caffeine and stress, which accelerate food flow, will
worsen Crohn's. Proteins that take longer to digest, such as Soy protein,
become allergens to Crohn's patients (suggesting that larger proteins are
somehow leaking into an area where an IgE response occurs.

4) Crohn's is characterized by chronic inflammation. If the immune system
was attacking the ileum, then the results would be quickly devastating.  I
think the damage to the ileum is slow because the damage is coming from
collateral damage... not a direct attack.

Therefore, I submit that Crohn's is the result of an immune response against
nutrients that are large enough to stimulate an immune response, with the
largest nutrients being attacked with an IgE response (food allergy). The
mechanism of how the large nutrients would escape the ileum into the
blood/lymph is still a mystery to me. Certainly car wrecks could do it...
releasing lots of nutrients into the blood and lymph and perhaps creating
food allergy. If MAP is a small bacteria, perhaps it is getting the blame
for causing Crohn's because it is merely leaking out of the ileum and
worsening inflamation.


> Mikael

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