Immunolgy Questions - Need answers and sources (journals, texts, etc.)

John Hasenkam johnh at
Sun Oct 17 07:33:03 EST 2004
<cerebralcineplex at> wrote in message
news:1097806013.659609.178750 at
> Hi I'm working on a take home project and we are supposed to get advice
> from professionals regarding the answers and list the sources. Can
> anyone help me with these questions? Max answer per question is 4 pages
> double spaced. Thanks!
> ** We must answer 1. choose ONE between 2. and 3. and choose another
> ONE between 4. and 5.
> 1. Describe and discuss the function of the common features of innate
> immunity of invertebrates and vertebrates.
> 2. The combining site for antigen of the MHC class I and II molecules
> are of different sizes. Describe and discuss the advantages and
> disadvantages for the host to have MHC class I and II molecules that
> are of different sizes.
> 3. An influenza epidemic has just be declared. The virologists have
> been able to isolate the virus (v-2004) from patients and they have
> determined that is very similar to a virus isolated 50
> years ago (v-1954). The virus (v-2004) is also similar to a virus
> isolated in 2003 (v-2003). Individuals that are 50 years of age and
> older have a fever that spikes within 48 hours of
> infection but the individuals all recover from the infection within 4
> days. Individuals that are 49 years old or younger have a fever within
> 48 hrs and recover from the infection after one month.
> Describe the nature of the antigen and antigenic determinants of the
> three viruses that play a role in protection of infection and recovery
> of disease (or the lack of protection of infection and recovery of
> disease.) (Assume that there is only one protein of the virus that is
> important on the immunological response to the virus.)
> 4. Given the importance of T cells in immune responses, why do you
> think the thymus involutes at puberty, and how is it that this process
> does not compromise the ability to mount immune responses after
> puberty? In your answer, provide a brief overview of the normal
> function of the thymus, and a brief description of the involution
> process (4 marks). I expect to see one or two concise hypotheses about
> why involution occurs (2 marks), and a discussion of the evidence to
> support or refute the hypotheses (4 marks). Lastly, why is it that
> involution, or even surgical removal of the thymus after puberty, has
> little effect on the functioning of the immune system (10 marks)?
> (maximum 2 pages, 4 pages double spaced, references not included).
> 5. After many years of focus on T cells, immunologists are recognizing
> important functions of B cells other than to produce immunoglobulins.
> Specifically, B cells may be important for the
> proper development of the spleen, and other lymphoid tissues (page 298
> in Janeway). Write a 2 page review (4 pages double spaced, references
> not included) on the factors important for the
> development of spleen, lymph nodes and Peyer's patches, specifically
> discussing the possible role of B cells in the development of the
> secondary lymphoid tissues.

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