[Immunology] Mouse allergy to human serum albumin

Peter Billingsley p.billingsley at abdn.ac.uk
Fri Apr 7 10:47:52 EST 2006

**** Please respond directly to me as I am not a subscriber to the immuno

We are wanting to use human serum albumin (HAS) as a carrier for a vaccine
in humans, but will need to run toxicity trials in mice and/or rabbits.  One
problem could be the supposed hyperimmune/allergic response in mice to HSA:
after the first jab, we are concerned that the mice (or a significant
proportion of them) could develop anaphylaxis.  Anyone come across this at
all in mice (especially) and rabbits? 

I have been spectacularly unsuccessful in finding any particularly useful
literature on this - so if anyone could point me in the direction of any
papers that would be a tremendous help.

Many thanks for you help.

Peter Billingsley


Dr Peter F Billingsley
School of Biological Sciences
University of Aberdeen
Tillydrone Avenue
Aberdeen AB24 2TZ, UK

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